Lesley Greene

Assoc Prof & Assoc Dean
Chemistry & Biochemistry

Contact Information

CHEMISTRY BUILDING 4501 ELKHORN AVE
NORFOLK, VA 23529

Email: lgreene@odu.edu

Phone: 757-683-6596

Education/Credentials

Web Link(s)

Greene Group

Expertise

Chemistry

Protein Biochemistry, Bioinformatics, Genetics
Research Interests

1. Protein Chemistry2. Molecular Biology and Genetic Engineering3. Bioinformatics and Genomics4. Protein Evolution5. Biophysics: Multidimensional heteronuclear NMR, Real-time 1D NMR & Photo-CIDNP, Circular dichroism & Fluorescence spectroscopy (equilibrium & stopped flow); Quenched flow HX.

Articles

Sori, N., Charron, J., and Greene, L. H. Insight into the structure, function and stability of the wheat temperature-induced lipocalin protein.

Bedford, J., Poutsma, J. L., and Greene, L. H. Persistence of Long-Range Interaction Networks during GB1 Unfolding Simulations.

Haratipour, Z., Aldabagh, H., Li, Y., and Greene, L. H. Network Analysis of Proteins Reveals Insights into the Determinants of the Greek-key Topology.

Collins, J. C., Bedford, J. T., and Greene, L. H. (2016). Elucidating the Key Determinants of Structure, Folding, and Stability for the (4 beta-alpha) Conformation of the B1 Domain of Protein G Using Bioinformatics Approaches. IEEE transactions on nanobioscience

Collins, J. C., and Greene, L. H. (2012). Biophysical analysis of the transition of an all α-helical Greek-key protein into amyloid fibrils composed of β-sheet structure. Protein and peptide letters, 19 (9), pp. 982-90.

Greene, L. H., and Grant, T. (2012). Protein folding by 'levels of separation': a hypothesis. FEBS letters, 586 (7), pp. 962-6.

Greene, L. H. (2012). Protein structure networks. Briefings in functional genomics, 11 (6), pp. 469-78.

Greene, L. H., Li, H., Zhong, J., Zhao, G., and Wilson, K. (2012). Folding of an all-helical Greek-key protein monitored by quenched-flow hydrogen-deuterium exchange and NMR spectroscopy. European biophysics journal (EBJ), 41 (1), pp. 41-51.

Li, H., and Greene, L. H. (2010). Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. PLoS One, 13, pp. e8654.

Li, H., Wojtaszek, J., and Greene, L. H. (2009). Analysis of conservation in the Fas-associated death domain protein and the importance of conserved tryptophans in structure, stability, and folding. Biochmica et Biophysica Acta - Proteins & Proteomics, 1794, pp. 583-593.

Higman, V. A., Rosner, H. I., Ugolini, R., Greene, L. H., Redfield, C., and Smith, L. J. (2009). Probing the urea dependence of nonrandom interactions in denatured human α-lactalbumin. J. Biomolecular NMR, 45, pp. 121-131.

Cuff, A., Redfern, O. C., Greene, L. H., Sillitoe, I., Lewis, T., Dibley, M., Reid, A., Pearl, F., Dallman, T., Todd, A., Garratt, R., Thornton, J., and Orengo, C. (2009). The CATH hierarchy revisited - structural divergence in domain superfamilies and the continuity of fold space. Structure, 17, pp. 1051-1062.

Greene, L. H., Lewis, T. E., Addou, S., Cuff, A., Dallman, T., Dibley, M., Redfern, O., Pearl, F., Nambudiry, R., Reid, A., Sillitoe, L., Yeats, C., Thornton, J. M., and Orengo, C. A. (2007). The CATh domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution. Nucleic Acids Research, 35, pp. D291-D297.

Greene, L. H., Wijesinha-Bettoni, R., and Redfield, C. (2006). Characterization of the molten globule of human-serum retinol-binding protein by NMR spectroscopy. Biochemistry, 45, pp. 9475-9484.

Higman, V. A., and Greene, L. H. (2006). Elucidation of conserved long-range interaction networks in proteins and their significance in determining protein topology. Physica A pp. 595-606.

Paci, E., Greene, L. H., Jones, R. M., and Smith, L. J. (2005). Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approach. FEBS J, 272, pp. 4826-4838.

Greene, L. H., and Higman, V. A. (2005). Conserved networks and the determinants of protein topology. FEBS J, 272, pp. Suppl. 1.

Neerathilingam, M., Greene, L. H., Colebrooke, S. A., Campbell, I. D., and Staunton, D. (2005). Quantitation of protein expression in a cell-free system: Efficient detection of yields and 19F NMR to identify folded protein. J Biomolecular NMR, 31, pp. 11-19.

Greene, L. H., Hamada, D., Eyles, S. J., and Brew, K. (2003). Conserved signature proposed for folding in the lipocalin superfamily. FEBS letters, 553 (1-2), pp. 39-44.

Greene, L. H., and Higman, V. A. (2003). Uncovering network systems within protein structures. Journal of molecular biology, 334 (4), pp. 781-91.

McCammon, M. G., Scott, D. J., Keetch, C. A., Greene, L. H., Purkey, H. E., Petrassi, H. M., Kelly, J., and Robinson, C. V. (2002). Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure (London, England : 1993), 10 (6), pp. 851-63.

Greene, L. H., Chrysina, E. D., Irons, L. I., Papageorgiou, A. C., Acharya, K. R., and Brew, K. (2001). Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein, a model for the lipocalin superfamily. Protein science : a publication of the Protein Society, 10 (11), pp. 2301-16.

Greene, L. H., Grobler, J. A., Malinovskii, V. A., Tian, J., Acharya, K. R., and Brew, K. (1999). Stability, activity and flexibility in alpha-lactalbumin. Protein engineering, 12 (7), pp. 581-7.
Book Chapters

Collins, J., and Greene, L. H. (2013). Conversion of all α-helical proteins into an alternative β-amyloid conformation.Bio-nanoimaging – Protein Misfolding and Aggregation. (pp. 485-501). Academic Press.

Gaforina, L., Sanchez, D., Greene, L. H., and Flower, D. R. (2006). The lipocalin protein family: Protein sequence and structure.Lipocalins. Georgetown, TX: Landes Biosciences and Eurekha.com.
Presentations

Barnes, C., Greene, L. H., and Lee, J. (March, 2019). Assessing the stability and expression of transgenes in genetically engineered cyanobacteria for biofuel production Poster presented at 257th American Chemical Society Orlando, FL.

Sacko, O., Barnes, C., Greene, L. H., and Lee, J. (March, 2019). Survivability of genetically engineered Thermosynechococcus elongatus BP1 in different temperature conditions Poster presented at 257th American Chemical Society Orlando, FL.

Haratipour, Z., Poutsma, J., and Greene, L. (March, 2019). Conserved long-range interaction networks, energetics and the determinants of protein topology Oral Presentation presented at 257th American Chemical Society National Meeting Orlando, FL.

Bedford, J., Poutsma, J., and Greene, L. (May, 2018). Persistence of key long-range interactions during GB1 unfolding simulations Oral Presentation presented at 96th Annual Meeting of the Virginia Academy of Science.

Haratipour, Z. (March, 2018). Characterization of long-range interaction networks in proteins using key network principles Oral Presentation presented at 255th American Chemical Society National Meeting.

Beford, J., Greene, L., and Poutsma, J. (March, 2018). Computational exploration of the β-grasp fold for structure, function, and stability Oral Presentation presented at 255th American Chemical Society National Meeting.

Haratipour, Z., and Greene, L. (May, 2017). The significance of the conserved long-ranged interaction networks in determining protein topology Oral Presentation presented at The 95th Virginia Academy of Sciences Annual Meeting.

Greene, L. H. (November, 2010). Greensboro, NC.

Greene, L. H. (June, 2010). presented at International Conference on Cold Plasma in Medicine Norfolk, VA.

Greene, L. H. (August, 2009). presented at 238th American Chemical Society National Conference Washington, DC.

Greene, L. H. (April, 2009). Conserved Protein Structure Networks Rock Hill, SC.

Greene, L. H. (October, 2008). Computational approaches to study protein structure and folding Hampton, VA.

Greene, L. H. (October, 2008). Conserved Protein Structure Networks Shippensburg, PA.

Greene, L. H. (October, 2008). Protein structure networks and the fold continuum Ashland, VA.

Greene, L. H. (April, 2008). Computational approaches to study protein structure and folding Norfolk, VA.

Greene, L. H. (March, 2008). Computational approaches to study protein structure and folding Lexington, VA.

Greene, L. H. (April, 2007). Computational approaches to study protein structure and folding Norfolk, VA.

Greene, L. H. (April, 2007). Computational approaches to study protein structure and folding Fairfax, VA.

Greene, L. H. (September, 2006). 'Bioinformatics to Proteomics' Course London, UK.

Greene, L. H. (July, 2005). presented at 30th FEBS Congress and 9th IUBMB Conference on Proteins Budapest, Hungary.
Artistic and Professional Performances and Exhibits

The Plight of the Dusky

Type: Novel

2017: John R. Broderick Diversity Champion Award, ODU President
2010: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)
2009: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)

Contracts, Grants and Sponsored Research

Greene, L. H. "Exploratory Look into the Future: Investigation Adaptation" $1,250. July 1, 2017 - June 30, 2018

Greene, L. H. "Exploratory look into the future: Investigating adaption and evolution of Synechococcus in response to high CO2 at the genomic-level" $2,500. State. July, 2017

Greene, L. H. "PURS" $10,000. 2016

Greene, L. H. "Vas Chrctztn Wheat Lipcln Vari" $1,250. July 1, 2014 - August 30, 2015

Greene, L. H. "Jeffress Grant" $20,000. State. 2009 - 2010

Greene, L. H. "SEECR Grant" $17,000. Old Dominion University. May, 2009 - August, 2009

Greene, L. H. "Jeffress Grant" $22,000. State. 2008 - 2008

Greene, L. H.; Luo, L.; Pothen, A.; Osgood, C. J.; Hatcher, P. G. "Elucidation of protein structure networks and beyond" $80,000. Old Dominion University. January 01, 2008 - June 30, 2008

Greene, L. H. "Multidisciplinary Grant" $80,000. Old Dominion University. January, 2008 - May, 2008

Greene, L. H. "Faculty Research Fellowship" $7,000. Old Dominion University. May, 2007 - August, 2007

Greene, L. H. "Engineering and Physical Sciences Research Council Grant (U.K.)" . 2002 - 2005

Greene, L. H. "Biotechnology and Biological Sciences Research Council Grant (U.K.)" $198,379. Other. 2002 - 2004

Greene, L. H. "Lockey Bequest Travel Awards" . 2002 - 2002

Greene, L. H. "International Research Fellows Award" $117,000. Federal. 2000 - 2002

Greene, L. H. "Lockey Bequest Travel Awards" . 2000 - 2000

Lesley Greene

Lesley Greene

Contact Information

Directory

Education/Credentials

Web Link(s)

Expertise

Research Interests

Articles

Book Chapters

Presentations

Artistic and Professional Performances and Exhibits

Contracts, Grants and Sponsored Research

Resources

Legal

Visit

Lesley Greene

Contact Information

Education/Credentials

Web Link(s)

Expertise

Research Interests

Articles

Book Chapters

Presentations

Artistic and Professional Performances and Exhibits

Contracts, Grants and Sponsored Research

Resources

Legal

Visit

Site Navigation

Site Navigation