Research Associate Professor
ADDRESS: IRP 2, 4211 Monarch Way, Norfolk, VA, 23508
Postdoctoral fellow, Old Dominion University, 2009-2012
Postdoctoral fellow, Virginia Commonwealth University, 2007-2009
Postdoctoral fellow, University Alabama at Birmingham, 2005-2007
M.S. Academy of Military Medical Sciences, 1997
M.D. Zhejiang University School of Medicine, 1991
Carol Zhou, Lab Technician
The research efforts in the Guo laboratory include (1) the development of enhanced electric pulse (EP) technologies for tumor eradication, (2) the elucidation of mechanisms of immune responses induced by nanosecond electric pulse (nsEP) tumor ablation, and (3) the development of EP based combination approaches for cancer therapy. Long-term goal is to facilitate safe and effective EP technology-based cancer therapies for clinical applications.
By investigating the mechanisms of nsEP tumor ablation, Dr. Guo's group demonstrated that a single nsEP treatment can trigger multiple actions nullifying the immunosuppression in tumor so antitumor immunity can be induced. This feature of nsEPs could be utilized to develop a novel in situ vaccination strategy as cancer immunotherapy, especially for poorly immunogenic cancers including breast cancer and pancreatic cancer.
Most relevant publications
- Guo S, Smeltz RB, Nanajian A, Heller R. (2021). IL‐15/IL‐15Rα heterodimeric complex as cancer immunotherapy in murine breast cancer models. Front Immunol. 2021 Feb 8;11: 614667.
- Guo S, Jing Y, Burcus NI, Lassiter BP, Tanaz R, Heller R, and Beebe SJ. (2018). Nano-pulse stimulation induces potent immune responses, eradicating local breast cancer while reducing distant metastases. Int J Cancer. 142(3): 629-40.
- Guo S, Burcus NI, Hornef J, Jing Y, Jiang C, Heller R, and Beebe SJ. (2018). Nano-pulse stimulation for the treatment of pancreatic cancer and the changes in immune profile. Cancers (Basel). 10(7): 217.
- Edelblute CM, Hornef J, Burcus NI, Norman, T, Beebe SJ, Schoenbach K, Heller R, and Guo S. (2017). Controllable moderate heating enhances the therapeutic efficacy of irreversible electroporation for pancreatic cancer. Scientific Reports. 7(1): 11767.
- Guo S, Donate A, Basu G, Lundberg C, Heller LC, and Heller R. (2011). Electro-gene transfer to skin using a noninvasive multielectrode array. J Control Release. 151(3): 256-62.
Awards and Honors
- 2019 Young Investigator Award, Frank Reidy Research Center for Bioelectrics, ODU