[ skip to content ]

More Information about this image

frrcbe-homepage-pic3

Bioelectrics News

Study by Professors Chen and Kong describes a novel and promising approach to overcome cancer drug resistance

February 21st 2022

frrcbe-kong-chen

Professors Chen and Kong with postdoctoral fellow Dr. Sudhir Bhatt.

The study led by Professors Hai-Lan Chen and Michael Kong from the Center for Bioelectrics, recently published in PNAS, shows the antitumor effects of trident cold atmospheric plasma (Tri-CAP), a reactive oxygen species-producing gas discharge. Tri-CAP simultaneously blocks three cancer survival pathways, including deregulated redox balance, glycolysis, and proliferative signaling, in a mouse cell line model of therapy-resistant chronic myeloid leukemia (CML). These effects trigger apoptotic cell death in CML cell lines and in primary CD34+ hematopoietic stem and progenitor cells from CML patients, while minimally affecting nonmalignant control cells. Tri-CAP also reduces tumor formation in vivo and prolonged the life of tumor-treated mice. To learn more ....


Site Navigation

Presidential Inauguration

ODU commemorated the inauguration of President Brian O. Hemphill, Ph.D., during Homecoming Weekend 2022. Relive the historic weekend.

Fall Open House

It's time to fall in love with ODU! Join us for our last Open House event of the semester on Saturday, November 19.

Commencement 2022

Visit the Commencement Office for information on event times, caps & gowns, tickets and more!