[ skip to content ]

More Information about this image


Bioelectrics News

NIH Grant Awarded for Early-Stage Neuromodulation Research

August 31st, 2022

bennet 2

Iurii Semenov with colleagues Allen Kiester, Joel Bixler and Bennett Ibey from the Air Force Research Laboratory during the installation of a strobe microscopy system at the Center in 2021

Dr. Andrei Pakhomov was awarded a 3-year, $640,000 R21 grant "Targeted Neuromodulation by Nanosecond Pulsed Electric Fields." This project is part of NIH Brain Initiative program and will generate new basic knowledge of neuronal function, including nanosecond-scale biophysics of the cell membrane and ion channels.

Nanosecond pulsed electric field (nsPEF) is a new modality for neuromodulation, with unique capabilities. Potential benefits of nsPEF include prolonged stimulation with little or no electrochemical side effects; excitation at lower thresholds; choosing between stimulation, inhibition, and ablation; and achieving these effects non-invasively, either for outpatient deep brain stimulation or for brain tumor ablation.

Dr. Pakhomov's team will utilize strobe pulsed laser microscopy to monitor the membrane potential in neurons with ~50-ns time resolution. This unique method will identify fine mechanisms and principles how nanosecond-duration electric stimuli excite and inhibit neurons. This new knowledge will guide the design of interference targeting protocols to achieve desired neuromodulation selectively at a distance from stimulating electrodes.

Site Navigation

Presidential Inauguration

ODU commemorated the inauguration of President Brian O. Hemphill, Ph.D., during Homecoming Weekend 2022. Relive the historic weekend.

Fall Open House

It's time to fall in love with ODU! Join us for our last Open House event of the semester on Saturday, November 19.

Commencement 2022

Visit the Commencement Office for information on event times, caps & gowns, tickets and more!